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CCR2 antagonist 5

Name: CCR2 antagonist 5
Brand: TargetMol
SKU: T27682
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27682Cas No. 1228650-83-6

Alias JNJ-41443532 Free Base, JNJ-41443532, JNJ41443532, JNJ 41443532

CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).JNJ-41443532 binds mCCR2 with a Ki of 9.6 µM, which can be used to study inflammatory diseases and diabetes. diseases and diabetes.

CCR2 antagonist 5

🥰Excellent

Purity: 99.98%

Catalog No. T27682Alias JNJ-41443532 Free Base, JNJ-41443532, JNJ41443532, JNJ 41443532Cas No. 1228650-83-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$668	In Stock	In Stock
50 mg	$949	In Stock	In Stock
100 mg	$1,290	In Stock	In Stock
200 mg	$1,730	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.98%

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).JNJ-41443532 binds mCCR2 with a Ki of 9.6 µM, which can be used to study inflammatory diseases and diabetes. diseases and diabetes.
Targets&IC50	CCR2 (mouse):9.6 μM (Ki), CCR2 (human):37 nM (IC50)
In vivo	CCR2 antagonist 5 (compound 8d) has good CV safety profile. It does not induce dose-dependent or notable effects on most cardiohemodynamic, functional respiratory, and electrophysiological parameters up to 10 mg/kg (i.v.) with plasma level at 70 µM in an anesthetized dog.[1] CCR2 antagonist 5 dose-dependently inhibits the influx of leukocytes, monocytes/macrophages, and T-lymphocytes into the peritoneal cavity with an ED50 of 3 mg/kg p.o. bid in a thioglycollate-induced peritonitis (TG) model.[1] CCR2 antagonist 5 has amendable oral bioavailability in dogs and primates.[1]
Synonyms	JNJ-41443532 Free Base, JNJ-41443532, JNJ41443532, JNJ 41443532

Chemical Properties

Molecular Weight	482.52
Formula	C₂₂H₂₅F₃N₄O₃S
Cas No.	1228650-83-6
Smiles	N(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)C2CN([C@@H]3CC[C@@](O)(CC3)C4=CN=CS4)C2
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (103.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.18 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0725 mL	10.3623 mL	20.7245 mL	103.6226 mL
5 mM	0.4145 mL	2.0725 mL	4.1449 mL	20.7245 mL
10 mM	0.2072 mL	1.0362 mL	2.0725 mL	10.3623 mL
20 mM	0.1036 mL	0.5181 mL	1.0362 mL	5.1811 mL
50 mM	0.0414 mL	0.2072 mL	0.4145 mL	2.0725 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc